The mystery of the power of people carrying other genes right inside us

The ancient marital marriages have left in some modern humans today a special genetic variation that determines their ability to cope with a number of diseases.

A team of scientists led by immunologist Shane Gray from the Garvan Medical Research Institute (Australia) has discovered a gene that does not really belong to modern humans Homo sapiens in the DNA of many members belonging to several special family.

As many studies have shown, the “human” in the modern world is actually just a late-born postpartum of the genus Homo sapiens (modern humans, smart people). Before Homo sapiens, many other species of the human genus roamed the earth, carrying different biological properties. Unfortunately, other human species became extinct one after another, only Homo sapiens survived and dominated his genus until now.

During the nomadic process, different species of the genus Homo encountered and mating of different species occurred. Therefore, in the DNA of some modern humans, Australian scientists have identified I207L, a genetic variation of Denisovans that purebred Homo sapiens do not have.

The impact of I207L on the body of those who wear it can be positive, neutral or negative. This variation makes the immune systems of “hybrid” Homo sapiens more powerful than other Homo sapiens. For many people, it is a golden gift from their ancestors, helping them to cope better with many diseases. But for some people, the immune system is overactive, leading to autoimmune diseases, severe inflammatory conditions.

However, after all, this variant is considered to have evolutionary benefits on the modern human immune system.

The finding is based on the genetic comparison of Denisovans’ remains unearthed in a mountain cave in Siberia and the DNA of some modern families with inherited inflammatory and autoimmune diseases. The work has just been published in the scientific journal Nature Immunology.

Previous studies have shown that the number of DNA carriers scattered throughout the world is numerous. A statistics in Papua New Guinean shows that the country has up to 5% of the Denisovans genome. Another study, published in July 1919 by New York University, confirmed that up to 40% of Asians have traces of different species marriages to Denisovans in the genome.

Unexpectedly, breathing exercises can save a lot of cancer patients

British scientists have found a way to make radiation therapy more effective in cancer just by helping patients practice … holding their breath.

The research team from Brimingham University (UK) has conducted a series of experiments at hospitals in New Castle (UK), Belgium, and the Netherlands and demonstrated the effectiveness of the method of breathing training to increase the power of radiation therapy. cancer.

30 cancer patients were provided with oxygen-rich air (60% concentration, nearly 3% higher than 21% of normal air), and increased carbon dioxide removal from the lungs by mechanical ventilation, wear as a mask. They trained for many days under expert supervision so that in the end, with a breath of oxygen-rich air, they could hold their breath for 6 minutes.

The purpose of this action is to … hold the patient’s chest and abdomen for 6 minutes.

Dr Mike Parkes, lead author of the study, said each breath caused the human chest and abdomen to move to 4 centimeters. Meanwhile, one of the key factors in the success of radiation therapy is keeping the patient’s body as still as possible.

In many cancer treatment units, doctors help patients practice holding their breath for short periods of time in order to help in that very small amount of time, the beams can find the most accurate target. With the ability to hold their breath for 6 minutes, the patients in the experiment were able to keep their bodies virtually motionless longer than others and thus the effectiveness of radiation therapy increased.

During a 65-minute treatment session, the patient will be instructed to hold his or her breath for about 41 minutes, divided into 9 sessions, with the remaining time available for establishing a holding session and restoring the breath after holding the breath.

It is not necessary for a patient to reach the level of 6 minutes for the therapy to be effective, because the normal person holds their breath for about 30 seconds. The patient is immediately resumed breathing if their systolic blood pressure rises to 180 mmHg. Up to 67% of volunteers can easily pass 6 minutes without ever reaching this limit.

The research has just been published in Radiotherapy & Oncology, the scientific journal of the European Association of Radiotherapy and Oncology.

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